1. Abstract
2. Composition of the Team
3. Research projets
4. Grants
5. Training

1. Abstract
The immune system is a complex biological system. Its study must take into account 3 levels of organization: organism, cells and molecules, in their space-time dimension and so to benefit from the approaches in biology of the complex systems, in particular of those of the systems immunology.

The objectives :

• Integrate & model experimental data linked to differentiation, diversity and dynamics of immune system and T cells in particular, at multi-system levels (organism, cell, molecule, time, space)
• Obtain a global analysis of the immune system behavior and T cell differentiation under physiological and pathological situations
• Develop bioinformatics & biostatistics tools and multidisciplinary interactions in the field of complex systems

Focus on T cells in physiology/physiopathologies

• Modeling T-cell differentiation & dynamics
• Global analysis of T cells : Gene expression & Immune repertoires
• Pharmacogenomics of T cells

 2. Composition of the team
Team leaders

• Véronique Thomas-Vaslin CR1 CNRS
• Adrien Six PU UPMC

Permanent Researchers

• Rima El Hage CR1 CNRS
• David Klatzmann Director I3, PU-PH UPMC
• Gilbert Bensimon MCU-PH UPMC
• Daniel Cohen PU UPMC
• Pierre-André Cazenave PU UPMC

Research assistants
Bruno Gouritin, immunology [AI UPMC]
Wahiba Chaara, bioinformatics [contract UPMC, AP-HP]
Nicolas Dérian, bioinformatics [contract UPMC, AP-HP]

Trainees
- Hang-Phuong Pham, Ph.D. biostatistics, UPMC, 2009-2012
- Benjamin Zerath, M1 M.Sc. bioinformatics, Univ. Evry Paris Sud, 2010

Former students
- Sébastien Le Mentec, M2 M.Sc. bioinformatics, Univ. Diderot (Paris VII), 2009
- Camille Baey, M1 M.Sc. immunology, UPMC, 2009
- Natalia Korneychuk, M1 M.Sc., immunology, UPMC, 2009
- Fei Xu, M1 M.Sc., immunology, UPMC, 2009
- Cira Dansokho, M1 M.Sc., immunology, UPMC, 2010

Fundings 

• UPMC
• CNRS
• Clinigene FP6
• Compuvac FP6 (terminated)

Ecole doctorale
Complexité du Vivant, UPMC