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 Integrative Immunology: Differentiation, Diversity, Dynamics (I2D3)

1. Abstract
2. Composition of the Team
3. Research activities
      -
Data mining
      - Lymphocyte Dynamics and Differentiation

1. Abstract

The immune system is a complex biological system. Its study must take into account 3 levels of organization: organism, cells and molecules, in their space-time dimension and so to benefit from the approaches in biology of the complex systems, in particular of those of the systems immunology.

The objectives :

  • Integrate & model experimental data linked to differentiation, diversity and dynamics of immune system and T cells in particular, at multi-system levels (organism, cell, molecule, time, space)
  • Obtain a global analysis of the immune system behavior and T cell differentiation under physiological and pathological situations
  • Develop bioinformatics & biostatistics tools and multidisciplinary interactions in the field of complex systems

Focus on T cells in physiology/physiopathologies

  • Modeling T-cell differentiation & dynamics
  • Global analysis of T cells : Gene expression & Immune repertoires
  • Research of biomarkers in immunopathologies (LabEx Transimmunom)
  • Understanding the complexity of the immune system (ImmunoComplexiT network)

 2. Composition of the team

Researchers
- Véronique Thomas-Vaslin, CR1 CNRS (I2D3 team leader)
- Adrien Six, PU UPMC (I2D3 team leader)
- Gilbert Bensimon, MCU-PH UPMC 
- Pierre-André Cazenave, PU UPMC
- David Klatzmann, PU-PH UPMC (director I3)

Trainees
- Walid Bedhiafi, Ph.D. bioinformatics, co-tutelle PDI MSC UPMC avec l'Universtité de Tunis, 2013-2016
- Wahiba Chaara
, Ph.D. bioinformatics, UPMC, 2013-2016
- Nicolas Dérian
, Ph.D. bioinformatics, UPMC, 2013-2016
- Mohamad J. Zeidan, Ph.D., UPMC, 2011-2014 (Prof. Management, American University of Beirut)

Visiting Scientist
- Prof. Hugues Bersini, Université Libre de Bruxelles (invited Professor UPMC, 2013)
- Chris McEwan
, postdoctoral fellow
- Alaa Abi-Haidar
, postdoctoral fellow

Former trainees
- Florence Giesen, M1 Ingénieur civil biomédical, ULB Polytechnique, 2013
- Afef Bouchouicha, M2 M.Sc. bioinformatics, Univ. Evry Val d'Essonne, 2013
- Hang-Phuong Pham, Ph.D. biostatistics, UPMC, 2009-2012
- Julien Vibert, M2 M.Sc. BMC, UMPC ENS-Paris, 2012
- Zakia Lakhdar-Barka, M1 M.Sc. immunology, UPMC, 2012
- Claire Lhuillier, M1 M.Sc. immunology, UPMC, 2011
- Benjamin Zerath, M1 M.Sc. bioinformatics, Univ. Evry Val d'Essonne, 2010
- Cira Dansokho, M1 & M2 M.Sc., immunology, UPMC, 2010-2011
- Sébastien Le Mentec, M2 M.Sc. bioinformatics, Univ. Diderot (Paris VII), 2009
- Camille Baey, M1 M.Sc. immunology, UPMC, 2009
- Natalia Korneychuk, M1 M.Sc., immunology, UPMC, 2009
- Fei Xu, M1 M.Sc., immunology, UPMC, 2009
- Emilie Franck, M2 M.Sc., immunology, UPMC, 2008
- Rachid Kerdous, M1 M.Sc., immunology, UPMC, 2008
- Anna Tchassovskikh, M2 M.Sc., immunology, UPMC, 2008

 Funding
- UPMC
- CNRS
- LabEx Transimmunom UPMC/CNRS/Inserm
- DHU i2B AP-HP

- Emergence UPMC
- Vieillissement CNRS
- Clinigene FP6 
- Compuvac FP6 (terminated)
- DIM-Problématiques transversales aux systèmes complexes. ISC-PIF
- PHC Tournesol-Egide
- PEPS CNRS Biologie Mathématiques Informatique

 Ecole doctorale
- Complexité du Vivant, UPMC


 
 
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